Relations exploratory factor analysis unrotated and varimax rotated internal consistency Cronbach's alpha convergent validity Pearson correlation coefficients between the QEQ total score and domain scores of the International Index of Erectile Function known-groups validity ability of the QEQ scores to differentiate between ED severity groups test-retest reliability Pearson correlation coefficient ; . RESULTS: The QEQ demonstrated excellent convergent and known-groups validity. Additional analysis demonstrated high internal consistency Cronbach's alpha, 0.92 ; . Item analysis demonstrated a unidimensional structure and suggested that satisfaction with hardness may be the key driver for satisfaction with overall quality of erections r 0.8 ; . The smaller exploratory study demonstrated good test-retest reliability r 0.82 ; . CONCLUSIONS: The QEQ is a six-item, patient-reported measure with a unidimensional structure, which produces a total score that may be transformed to a 0-100 scale. Psychometric analysis confirmed reliability and validity of the QEQ, which solely and specifically evaluates satisfaction of men with the quality of their erections. The QEQ is a potentially useful measure for monitoring and evaluating treatment in those who are bothered by, or concerned about, their erectile function.
Augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood. 1987; 69: 109-116. Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, Dover GJ. Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea. Blood. 1997; 89: 1078-1088. Rodgers GP, Dover GJ, Noguchi CT, Schechter AN, Nienhuis AW.

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FIG. 6. Case 2. Medication, blood pressure, and azotemia are indicated on the same time axis for three different periods. The figures for blood pressure and medication are weekly averages and represent 35 recorded values at home and 42 in the hospital; the pressure readings were taken with the patient in a sitting position. The oral dosage of hexamethonium chloride is represented by solid bars and that of pentolinium tartrate by cross-hatched ones.
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INULIN-AND PAH-CLEARANCE RESULTS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS USING A NEW COMPUTERIZED DOSEFINDING-ALGORITHM WITH ASCITBS-VOLUME ADJUSTMENTS. Brensinq Karl August: Jdrg Ferber, Peter Raab, Peter Schiedermaier, Jolanta Perz, Hans Ulrich Klehr, Tilman Sauerbruch. Department of General Medicine, University of Bonn, Germany. Introduction: Impaired renal function and fluid balance often complicate liver cirrhosis and due to reduced muscle mass Inulin IN ; PAH clearance CL ; is recommended for subtle pathophysiological diagnostic. Routine INand PAH-test-dose estimations based on body-weight appeared inadequate for optimal steady state IN PAH serum levels especially in ascitic patients with decompensated cirrhosis. Methods: We tested a new computerized algorithm for bolus and constant infusion IN PAH doses based on weight height, endog.CL and US-estimated ascites volume in 15 cirrhotics 50 + 11Y; 9M; 6F; Child 7A B, 8C ; with moderate 5x ; and severe 9x ; ascites and S-creatinine levels 2 mg dl. After an IV-bolus of IN PAH and a 2h equilibration period we estimated the endogenous creatinine clearance end.CL ; and the IN PAH clearance for three 20-Min-intervals based on serum and urin levels. IN PAH levels were determined by coloraetry. Results: Mean S-creatinine levels were 1.3 + 0.4 mg dl and all tested pts achieved acceptable steady state IN PAH serum levels over three 20-Min-clearance intervals. The mean endog.CL was higher than mean IN-CL 60 + 46 vs. 43 + 18 min; p 0.05 ; . The PAH-CL was 293 141 ml min. Age adapted GFR -56 + 21% ; , RPF -44 + 23% ; and filtration fraction FF: 15.7 4% ; were markedly reduced. IN-CL was neg. correlated with ascites r 0.7; p 0.05 ; and bilirubin r 0.8; p 0.02 ; . Conclusions: 1 ; Endogenous creatinine clearance overestimate the GFR by almost 50% and is unreliable in these pts. 2 ; Thr tested iN PAH-dose-finding algorithm including ascites volume estimation achieves reliable steady state IN PAH serum levels in these pts. 3 ; The marked GFR and FF reduction indicate a higher vas afferens tonus resulting in a relatively reduced glomerular perfusion in pts with decompensated liver cirrhosis.

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